Turbulent Times in the Cerebrovasculature (and What Endothelial Cells Have to Say About It)
Dr. Tamie Poepping
Professor, Physics and Astronomy
Western University
Date: Friday, March 1, 2024
Time: 1–2 p.m. EST
Host: Eno Hysi
Location: In-person and virtual
Li Ka Shing Knowledge Institute, Auditorium, and via Zoom
Refreshments will be served.
Lecture Takeaways
The main takeaways are as follows:
- Turbulent flow plays a pronounced role in vascular health, yet that role is poorly understood. The carotid artery bifurcation is a site prone to the development of atherosclerosis and serves as a good example for demonstrating the evolution of flow disturbances and flow-related forces.
- Microfluidic ‘lab-on-a-chip’ devices enable the recapitulation of disturbed shear stress in an endothelial cell environment, illustrating that endothelial cell response varies with the level of shear stress fluctuations in magnitude and direction.
Biography
Dr. Tamie Poepping is a Professor in the Department of Physics & Astronomy at Western University. Her research involves studying complex blood flow in vivo and in life-size models to reveal the physical forces that may contribute to disease development and progression. To complement this work, microfluidic ‘lab-on-a-chip’ devices are being developed for recapitulating these flow environments to study how endothelial cells perceive and respond to these forces.
No sign-up is required. For more information, contact the iBEST coordinator at ibest@torontomu.ca.
